The Pawpaw
Asimina triloba
References

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1. Rupprecht, J.K.,C.-J. Chang, J.M. Cassady, J.L. McLaughlin, K.L. Mikolajczak, and D.Weisleder, "Asimicin, a new cytotoxic and pesticidal acetogenin from the paw paw, Asimina triloba (Annonaceae)," Heterocycles, 24, 1197-1201 (1986).
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3. Hui, Y,-H., J.K. Rupprecht, Y-M. Liu, J.E. Anderson, D.L. Smith, C.-J. Chang, and J.L.McLaughlin, "Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullta," Journal of Natural Products, 52, 463-477 (1989).
4. Zhao, G.X., Y.-H. Hui, J.K. Rupprecht, J.L. McLaughlin, and K.V. Wood, "Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba," Journal of Natural Products, 55, 347-356 (1992).
5. Zhao, G.X., Z.-M. Gu, L. Zeng, J.-F. Chao, K.V. Wood, J.F. Kozlowski, and J.L. McLaughlin, "The absolute configuration of trilobacin and trilobin, a novel highly potent acetogenin from the stem bark of Asimina triloba (Annonaceae)," Tetrahedron 51, 7149-7160 (1995).
6. Rieser, M.J., Y.H. Hui, J.K. Rupprecht, J.F. Kozlowski, K.V. Wood, J.L. McLaughin, T.R. Hoye, P.R. Hanson, and Z.P. Zhuang, "Determination of absolute configuration of stereogenic carbinol centers in annonaceous acetogenins by 1H- and 19F- NMR analysis of Mosher ester derivatives", Journal of the American Chemical Society, 114,10203-10213 (1992).
7. Lewis, M.A., J.L. Arnason, B.J.R. Philogene, J.K. Rupprecht, and J.L. McLaughlin. "Inhibition of respiration at site I by asimicin, an insecticidal acetogenin of the paw paw, Asimina triloba (Annonaceae)," Pesticide Biochemistry and Physiology, 45, 15-23 (1993).
8. Hollingworth, P.M., K.I. Ahammadsahib, G. Gadelhak, and J.L. McLaughlin, "New inhibitors of complex I of the mitochondrial electron transport chain with activity as pesticides", Biochemical Society Transactions, 22, 230-233 (1994).
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10. Landoit, J.L., K.I. Ahammadsahib, R.M. Hollingworth, R. Barr, F.L Crane, N.L. Buerck, G.P. McCabe, and J.L. McLaughlin, "Determination of structure-activity relationships of annonaceous acetogenins by inhibition of oxygen uptake in rat liver mitochondria," Chemico-Biological Interactions, 98, 1-13 (1995).
11. Alfonso, D., H.A. Johnson, T. Colman-Saizarbitoria, C.P. Presley, G.P. McCabe, and J.L. McLaughlin, "SARs of annonaceous acetogenins in rat liver mitochondria," Natural Toxins. 4. 181-188 and erratum 295 (1996).
12. He, K., G.-X.Zhao, G. Shi, L. Zeng, J.-F. Chao, and J.L. McLaughlin, "Additional bioactive annonaceous acetogenins from Asimina triloba (Annonaceae)," Bioorganic and Medicinal Chemistry, 5, 501-506 (1997).
13. Morre, D.J., R. de Cabo, C. Fariey, N.H. Oberlies, and J.L. McLauglin, “Mode of Action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HELA and HL-6C but not liver, plasma membranes," Life Sciences, 56, 343-348 (1995).
14. Satake S., M. Kuzuya, H. Miura, T. Asai, M.A. Ramos, M. Muraguchi, Y. Ohmoto. and A. Iguchi, "Up-regulation of vascular endothelial growth factor in response to glucose deprivation." Biology of the Cell, 90, 161 -168 (1998).
15. Moser, T.L., M.S. Stack, I. Asplin, J.J. Enghild, P. Hojrup, L. Everitt, S. Hubcnak. H.W, Schnaper, and S.V. Pizzo, "Angiostatin binds ATP synthase on the surface of human endothelial cells," Proceedings of the National Academy of Sciences of the United States of America. 96. 2811-2816(1999).
16. Morin MJ, "From oncogene to drug: development of small molecule tyrosine kinase inhibitors and anti-tumor and anti-angiogenic agents," Oncogene, 19, 6574-6583 (2000).
17. Johnson, H.A., N.H. Oberlies, F.Q. Alali, and J.L. McLaughlin, "Thwarting resistance:
annonaceous acetogenins as new pesticidal and antitumor agents," in Biologically Active Natural Products: Pharmaceuticals ACS Symposium Book, Las Vegas, Nevada, eds. H. Cutler and S. Cutler, CRC Press, Boca Raton (1999), pp. 173-183.
18. Oberlies, N.H., F.Q. Alali, and J.L. McLaughlin, "Annonaceous acetogenins: tnwarting ATP dependent resistance," in New Trends and Methods in Natural Products Research, eds. I. Calis, T. Ersoz, and A.A. Basaran, Proceedings of the 12th International Symposium on Plant Originated Crude Drugs, May 20-22, 1998, The Scientific and Technical Research Council of Turkey. Ankara pp. 192-223(1999).
19. Oberlies, N.H., C.-J. Chang, and J.L. McLaughlin, "Structure-activity relationships of diverse annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF- 7/adr) cells," Journal of Medicinal Chemistry, 40, 2102-2106 (1997).
20. Oberlies, N.H.,V.L. Croy, M.H. Harrison, and J.L.McLaughlin, 'The Annonaceous acetogenin bullatacin is cytotoxic against multidrug resistant human mammary adenocarcinoma cells," Cancer Letters, 115, 173-179 (1997).
21. Oberlies, N.H., J.L. Jones, T.H. Corbett, S.S. Fotopoulos, J.L. McLaughlin, "Tumor cell growth inhibition of annonaceous acetogenins in an in vitro disk diffusion assay, Cancer Letters, 96, 55- 62 (1995).
22. Shimada, H., J.B. Grutzner, J.F. Kozlowski, and J.L. McLaughlin, "Membrane conformations and their relation to cytotoxicity of asimicin and its analogues," Biochemistry, 37, 854-866 (1998).
23. Shimada, H., J.F. Kozlowski, and J.L. McLaughlin, "The positions in liposomal membranes of the tetrahydrofuran ring moieties of the annonaceous acetogenins, annonacin and sylvaticin, as determined by NMR spectroscopy," Pharmacological Research, 37, 357-384 (1998).
24. Miyoshi, H., M. Ohshima, H. Shimada, T. Akazi, H. Iwamura, and J.L. McLaughlin, "Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I," Biochimica Biophysica Acta, 1365, 443-452 (1998).
25. Guadano, A., C. Gutierrez, E. de la Pena, D. Cortes, and A. Gonzales-Coloma, "Insecticidal and mutagenic evaluation of two annonaceous acetogenins", Journal of Natural Products, 63, 773-776 (2000).


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